Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length286 amino acids

Chemical FormulaC1434H2230N388O405S6

DescriptionStandard

        TNPGFVVRITQAGLDYAHQHGVAVLEKELAQLKLPDISGDFHIRHVGKVRYEISRLDLRSFHLPYSRISLVPNVGLQVAISNAFAELDGVKIHFIRDHGSFDLKVDNVYIKINLRLGNDASGKPTVSTSDCSTHISKVRVHFSGRFGWLYNLFYKAVESRFRTILEDKVCEIVVSSVRSELQPYLQTLPVTARIDAMTGIDYSLVAPPIATARSLDVGLKGEFFSLARRSAVPFPPGVLTLPPDHDRMVYFGASSYFFNTASFAYHAAGALVFEITDAMVSSAGGM
    

Molecular Weight31577.79 Da

Isoelectric Point (pI)8.46

Net Charge (pH 7.0)2.36

Net Charge (pH 7.4) 1.53

Charge Density (pH 7.0) 0.0083

GRAVY Index0.09

Hydrophobic Moment 0.58

Boman Index0.11

Instability Index35.38

Aliphatic Index 96.78

Aromaticity 0.1049

Extinction Coeff. Reduced 21890.00

Extinction Coeff. Oxidized 22015.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0057790 VERIFIED: NO

Provenance & Taxonomy

OrganismAntrostomus carolinensis [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria