Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length459 amino acids

Chemical FormulaC2328H3645N605O673S19

DescriptionStandard

        MARPHCAVVVLLLLAVVSGLEEGASNPGFVARITRKGLEYARQYGVAILKKELSTIELPDLSGSIKVSWIKIMSYEFYRLKIHDFELRNSDLRLCPRQGVRASLSNNYVSVSGNWKIKKAFISFDGTFDMKVDDICISAFLNLGKDQSGRLTASMAHCNNSIGHISIDISGKLSWILNLFHERIENKFKNILEQKICEMVGKATTSRLEPYLQTLPVISMIDQVASIDYSLIGAPQVTSQVLDTPFKGEFFGQNGHSRAPFDAPPIRLPEKHDYMVYFAISEYVFNTASWVYHQAGYMNFTIQNQHLARMYPNMELELEMSPESAPLLMFTPGNVTLMPVIDVQAFALKPNSSDRKPLFQLRVTTSISATINVSSDRIVGSVTPGSKLKLELKHSNINFIDVELMEVILNYYALHTIYPSLNAKLEEGFPLPLPVDTYLNSSELQVHEVSETWGLGGEF
    

Molecular Weight51485.73 Da

Isoelectric Point (pI)6.20

Net Charge (pH 7.0)-4.44

Net Charge (pH 7.4) -5.46

Charge Density (pH 7.0) -0.0097

GRAVY Index-0.02

Hydrophobic Moment 0.84

Boman Index0.10

Instability Index33.86

Aliphatic Index 97.47

Aromaticity 0.0959

Extinction Coeff. Reduced 52830.00

Extinction Coeff. Oxidized 53080.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0063628 VERIFIED: NO

Provenance & Taxonomy

OrganismVulpes vulpes [Bacterium]

FamilyBPI

Tax ID9627

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence