Peptide Database

Peptide NameSLAY-screened peptide P2921

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC100H160N32O29S2

DescriptionStandard

        RSTAQTYRRLADRYMLSFC
    

Molecular Weight2338.67 Da

Isoelectric Point (pI)10.04

Net Charge (pH 7.0)2.75

Net Charge (pH 7.4) 2.53

Charge Density (pH 7.0) 0.1447

GRAVY Index-0.64

Hydrophobic Moment 0.69

Boman Index-0.33

Instability Index64.57

Aliphatic Index 51.58

Aromaticity 0.1579

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1036.49

LogP -11.38

H-bond Donors 41.0

H-bond Acceptors 34.0

Rotatable Bonds 76.0

Heavy Atoms 163.0

Ring Count 3.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0112395 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/