Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length463 amino acids

Chemical FormulaC2287H3651N577O653S19

DescriptionStandard

        MSPCSLLALLAVISLTLAASPGVKVKLTDKGIEYGMFEIGMASLQQKLKTIKVPDLSGTEKVPPIGKVKYSLTGMTIVNLGLPKSALVLMPGTGVRLAITNAFINLHGNWRVRYFRFIQDHGSFDLTVNGLTITADIAIKSDETGRPTVSTVNCVANVGSASIKFHGGASWLYNLFKSYIDKALRSALQKQICPLVADVITDMNPHLKTFNVLAKVDQYAEIEYSMVTSPTISKSSIEFSLKGEFYNIGKHQEPPFSPTPFSLPPQDNNMLYIGVSSFTPNSAGFVYNNAGALSLHVTDDMIPPSSPIRLNTGTFGVFIPEIAKRFPGMMMKLLVKTVKEPTISLEPNNVTVQASGTVTAYAIQPNTTLSPLFVLNMVTFSISAGGPSNTDQSKLILYVGQFQVQPLDNIFLMVLKVVVIPKVNARLEKGFPLPTIGKMNLINTQLQVLKDYMLIGTDVQFTG
    

Molecular Weight50287.16 Da

Isoelectric Point (pI)9.22

Net Charge (pH 7.0)9.01

Net Charge (pH 7.4) 8.35

Charge Density (pH 7.0) 0.0195

GRAVY Index0.19

Hydrophobic Moment 0.70

Boman Index0.18

Instability Index33.18

Aliphatic Index 100.80

Aromaticity 0.0821

Extinction Coeff. Reduced 30370.00

Extinction Coeff. Oxidized 30495.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0132086 VERIFIED: NO

Provenance & Taxonomy

OrganismOncorhynchus tshawytscha [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence