Peptide Database

Peptide Namehuman defensin HNP-4

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Standard StatusStandard

Sequence Length33 amino acids

Chemical FormulaC157H261N49O43S6

DescriptionStandard

        VCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRV
    

Molecular Weight3715.44 Da

Isoelectric Point (pI)8.98

Net Charge (pH 7.0)3.68

Net Charge (pH 7.4) 3.37

Charge Density (pH 7.0) 0.1114

GRAVY Index0.66

Hydrophobic Moment 0.59

Boman Index0.03

Instability Index62.04

Aliphatic Index 91.21

Aromaticity 0.0909

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1505.79

LogP -16.53

H-bond Donors 63.0

H-bond Acceptors 53.0

Rotatable Bonds 120.0

Heavy Atoms 255.0

Ring Count 3.0

Amide Bonds 33.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0407682 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Familyalpha-defensin family

Tax ID9606; 0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide2-30; 4-19; 9-29

Bio-Activity Profile

Function

Antimicrobial alpha-defensin family Antibacterial Antifungal Host defense Defensin-like

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