‹ ›
MYP_104142
← PREVIOUS NEXT → BACK
Basic Information
human defensin HNP-4
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
33 amino acids
C157H261N49O43S6
Standard
Sequence
VCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRV
Physicochemical Analysis
3715.44 Da
8.98
3.68
3.37
0.1114
0.66
0.59
0.03
62.04
91.21
0.0909
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1505.79
-16.53
63.0
53.0
120.0
255.0
3.0
33.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0012356 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperWilde C. G., Griffith J. E., Marra M. N., Snable J. L., Scott R. W.. Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family. J. Biol. Chem., 264, 11200-11203, 1989.
RECORD: Rec_0036799 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
2-30; 4-19; 9-29
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anti-SARS-CoV-2
Escherichia coli ATCC 8739 (vLD50=3.3±0.4 μg/ml)
PaperHuman Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry. Viruses. 2021 Jun 26;13(7):1246. doi: 10.3390/v13071246. PMID: 34206990. | PubMed PMID: 17088326 | PubMed PMID: 15620707 | Antibacterial activity and specificity of the six human alpha-defensins. Antimicrob Agents Chemother. 2005 Jan;49(1):269-275. doi: 10.1128/AAC.49.1.269-275.2005. PMID: 15616305. PMID34206990;17088326;15620707;15616305 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34206990/
RECORD: Rec_0056193 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID4056036 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/4056036/
RECORD: Rec_0068125 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
2-30; 4-19; 9-29
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anti-SARS-CoV-2
aureus ATCC 29213 (vLD50=7.2±0.2 μg/ml)
PaperHuman Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry. Viruses. 2021 Jun 26;13(7):1246. doi: 10.3390/v13071246. PMID: 34206990. | PubMed PMID: 17088326 | PubMed PMID: 15620707 | Antibacterial activity and specificity of the six human alpha-defensins. Antimicrob Agents Chemother. 2005 Jan;49(1):269-275. doi: 10.1128/AAC.49.1.269-275.2005. PMID: 15616305. PMID34206990;17088326;15620707;15616305 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34206990/
RECORD: Rec_0117923 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli MG1655
10 μM
MBC
PMID28423004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28423004/
1 2 3 ... 6 NEXT LAST
Showing 5 records on this page · Page 1 of 6