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MYP_104102
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Basic Information
TIMP-3 Tail
Anticancer
Wound healing/Regeneration ▸ Angiogenesis modulation ▸ Anti-angiogenic
Standard
22 amino acids
C114H161N29O33S
Standard
Sequence
GYCSWYRGWAPPDKSIINATDP
Physicochemical Analysis
2497.74 Da
5.95
-0.25
-0.47
-0.0114
-0.73
0.50
0.03
3.14
44.55
0.1818
13980.00
13980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
986.39
-8.65
35.0
34.0
70.0
177.0
9.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0016506 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
TIMP-3
9606
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
VEGF binding inhibition VEGFR-2 signaling inhibition Endothelial migration inhibition Endothelial proliferation inhibition Anti-angiogenic Anticancer
vascular endothelial growth factor receptor 2 (VEGFR-2)
5 μM
IC50 (competitive ELISA)
PaperTissue Inhibitor of Metalloproteinases-3 Peptides Inhibit Angiogenesis and Choroidal Neovascularization in Mice. PLoS One. 2013;8(3):e55667. DOI:10.1371/journal.pone.0055667 PMID23469166 Evidence URLhttps://patents.google.com/patent/US8431396B2 PatentUS8431396B2
RECORD: Rec_0182286 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
VEGF binding inhibition VEGFR-2 signaling inhibition Endothelial migration inhibition Endothelial proliferation inhibition Anti-angiogenic Anticancer
vascular endothelial growth factor receptor 2 (VEGFR-2)
5 μM
IC50 (competitive ELISA)
PaperTissue Inhibitor of Metalloproteinases-3 Peptides Inhibit Angiogenesis and Choroidal Neovascularization in Mice. PLoS One. 2013;8(3):e55667. DOI:10.1371/journal.pone.0055667 PMID23469166
RECORD: Rec_0370409 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
VEGF binding inhibition VEGFR-2 signaling inhibition Endothelial migration inhibition Endothelial proliferation inhibition Anti-angiogenic Anticancer
vascular endothelial growth factor receptor 2 (VEGFR-2)
5 μM
IC50 (competitive ELISA)
PaperTissue Inhibitor of Metalloproteinases-3 Peptides Inhibit Angiogenesis and Choroidal Neovascularization in Mice. PLoS One. 2013;8(3):e55667. DOI:10.1371/journal.pone.0055667 PMID23469166;26335203 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26335203/