Peptide Database

Peptide NameBradykinin-potentiating peptide 5a2

Function Ontology

Cardiovascular

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Hormonal / Endocrine ▸ Hormone peptide

Membrane / Ion-channel modulation ▸ Ion channel modulation

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length5 amino acids

Chemical FormulaC30H44N8O7

DescriptionStandard

        QKWAP
    

Molecular Weight628.72 Da

Isoelectric Point (pI)8.75

Net Charge (pH 7.0)0.76

Net Charge (pH 7.4) 0.55

Charge Density (pH 7.0) 0.1518

GRAVY Index-1.62

Hydrophobic Moment 0.48

Boman Index-0.16

Instability Index16.46

Aliphatic Index 20.00

Aromaticity 0.2000

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 255.83

LogP -1.02

H-bond Donors 8.0

H-bond Acceptors 8.0

Rotatable Bonds 17.0

Heavy Atoms 45.0

Ring Count 3.0

Amide Bonds 5.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0060131 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops jararaca [Animal]

FamilyBradykinin-potentiating peptide 5a2

Tax ID8724

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Enzyme modulation Ion channel modulation Receptor modulation ACE inhibitory

Targetthe cell

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0090311 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops jararaca [Animal]

FamilyBradykinin-potentiating peptide 5a2

Tax ID8724

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Enzyme modulation Ion channel modulation Receptor modulation ACE inhibitory

Targetangiotensin-converting enzyme

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0231193 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops jararaca [Animal]

FamilyBradykinin-potentiating peptide 5a2

Tax ID8724

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Enzyme modulation Ion channel modulation Receptor modulation ACE inhibitory

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0289763 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops jararaca [Animal]

FamilyBradykinin-potentiating peptide 5a

Tax ID8724

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Enzyme modulation Ion channel modulation Receptor modulation ACE inhibitory

TargetB2 receptor

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0417801 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops jararaca [Animal]

FamilyBradykinin-potentiating peptide 5a2

Tax ID8724

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Enzyme modulation Ion channel modulation Receptor modulation ACE inhibitory

TargetHEK 293 cells

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour