Peptide Database

Peptide NameT21N17

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length38 amino acids

Chemical FormulaC210H354N64O56

DescriptionStandard

        RIQQIEQKIHHIEQRIQQIEQLLQLTVWGIKQLQARIL
    

Molecular Weight4671.45 Da

Isoelectric Point (pI)9.98

Net Charge (pH 7.0)1.94

Net Charge (pH 7.4) 1.63

Charge Density (pH 7.0) 0.0511

GRAVY Index-0.37

Hydrophobic Moment 0.62

Boman Index-0.07

Instability Index103.59

Aliphatic Index 143.68

Aromaticity 0.0263

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2013.94

LogP -14.42

H-bond Donors 67.0

H-bond Acceptors 60.0

Rotatable Bonds 168.0

Heavy Atoms 330.0

Ring Count 4.0

Amide Bonds 47.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0207245 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetHIV-1

RECORD: Rec_0310145 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermNone

DisulfideDisulfide bond(s) reported

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHIV-1(human immunodeficiency virus 1):inhiition of cell-cell fusion between TZM-bl cells and HL2/3 cells

Activity0.251±0.0411 μM

MethodIC50

RECORD: Rec_0341415 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1 (human immunodeficiency virus 1) | TZM-bl cells; HL2/3 cells

Activity0.251±0.0411 μM

MethodIC50

Half-LifeMammalian: 1 h; Yeast: 2 min; E. coli: 2 min

PaperSuitable fusion of N-terminal heptad repeats to achieve covalently stabilized potent N-peptide inhibitors of HIV-1 infection. | Lai W, Wang C, Yan J, Liu H, Zhang W, Lin B, Xi Z. | Bioorg Med Chem. 2020 Feb 15;28(4):115214. | DOI:10.1016/j.bmc.2019.115214 | PMID:31932193 PMID31932193 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31932193/