Peptide Database

Peptide NameHuman Glandular Kallikrein 2 (hK2)-activated thapsigargin prodrug

Function Ontology

Anticancer

Standard StatusStandard

Sequence Length6 amino acids

Chemical FormulaC32H55N13O7

DescriptionStandard

        GKAFRR
    

Molecular Weight733.86 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)2.76

Net Charge (pH 7.4) 2.55

Charge Density (pH 7.0) 0.4598

GRAVY Index-1.45

Hydrophobic Moment 1.00

Boman Index-0.71

Instability Index89.65

Aliphatic Index 16.67

Aromaticity 0.1667

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 358.64

LogP -3.63

H-bond Donors 14.0

H-bond Acceptors 10.0

Rotatable Bonds 25.0

Heavy Atoms 52.0

Ring Count 1.0

Amide Bonds 5.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0420133 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermNone

Other ModsLigated with potent cytotoxin thapsigargin, L12ADT

Bio-Activity Profile

Function

Anticancer

Activity1250 μM

MethodIC50

Half-LifeBalb-C mice, in vivo; 2400 s