Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length398 amino acids

Chemical FormulaC1986H3169N515O559S14

DescriptionStandard

        MARGPDDTWRWATLVVLAALSTAVTATTSPGVVARITQKGLDYACQQGVATLQKELEKVTIPTFSGSFKMKYLGKGKYSFYSLVIREFKLPNSQIRPLPGQDLDLSIKDASIKISGKWKARKNFIKVSGNFDLSVEGISILAGLKLGYVPTSGHPTVTCSSCSSHINSVRVRISRSSLGWLIQLFRKKIESSLRNSMNRKICKVVTSTVSSKLQPYFQTLPVTTKIDNVAGIDYSLVAPPKATADNLDVLLKGEFFRLAHRGPPPFAPPALTLPNDHNRMVYLGISEYLFNTAGLVYQEAGVLNFTLSDDTLPKESKFLLTTKSFGTLLPQVAKMFPDMKMQLLIWASSPPNIAVCPTGLHLTFALDTQAVAVLPDSSLAPLFLLEMGLRLEPLSYCF
    

Molecular Weight43653.43 Da

Isoelectric Point (pI)9.55

Net Charge (pH 7.0)15.89

Net Charge (pH 7.4) 15.24

Charge Density (pH 7.0) 0.0399

GRAVY Index0.08

Hydrophobic Moment 0.69

Boman Index0.11

Instability Index35.04

Aliphatic Index 97.99

Aromaticity 0.0879

Extinction Coeff. Reduced 43890.00

Extinction Coeff. Oxidized 44265.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0310833 VERIFIED: NO

Provenance & Taxonomy

OrganismDelphinapterus leucas [Animal]

FamilyBPI

Tax ID9749

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence