Peptide Database

Peptide NamePAW

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Enzyme modulation ▸ Enzyme inhibition ▸ Reverse transcriptase inhibition

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC89H134N20O27S

DescriptionStandard

        GTKWLTEWIPLTAEAEC
    

Molecular Weight1948.20 Da

Isoelectric Point (pI)4.25

Net Charge (pH 7.0)-2.24

Net Charge (pH 7.4) -2.47

Charge Density (pH 7.0) -0.1319

GRAVY Index-0.12

Hydrophobic Moment 0.43

Boman Index0.20

Instability Index38.32

Aliphatic Index 80.59

Aromaticity 0.1176

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 750.32

LogP -4.29

H-bond Donors 27.0

H-bond Acceptors 26.0

Rotatable Bonds 59.0

Heavy Atoms 137.0

Ring Count 5.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0347173 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

Targetinhibition of PHA-P-activated PBMCs infected with HIV-1-LAI

Activity0.0018 μM

MethodEC50

RECORD: Rec_0366855 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Replication inhibition

Targetinhibition of PHA-P-activated PBMCs infected with HIV-1-LAI

Activity0.0018 μM

MethodEC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperA new generation of peptide-based inhibitors targeting HIV-1 reverse transcriptase conformational flexibility. | Agopian A, Gros E, Aldrian-Herrada G, Bosquet N, Clayette P, Divita G. | J Biol Chem. 2009 Jan 2;284(1):254-264. | DOI:10.1074/jbc.M802199200 | PMID:18952602 PMID18952602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18952602/

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