Peptide Database

Peptide NamePYLa PGLa A [Cleaved into: PYLa; PGLa; PGLa-H]

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive ▸ Anti-Staphylococcus aureus

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Standard StatusStandard

Sequence Length64 amino acids

Chemical FormulaC298H495N83O88S5

DescriptionStandard

        MYKQIFLCLIIAALCATIMAEASAFADADEDDDKRYVRGMASKAGAIAGKIAKVALKALGRRDS
    

Molecular Weight6808.95 Da

Isoelectric Point (pI)8.68

Net Charge (pH 7.0)1.48

Net Charge (pH 7.4) 1.22

Charge Density (pH 7.0) 0.0232

GRAVY Index0.27

Hydrophobic Moment 0.62

Boman Index0.08

Instability Index31.05

Aliphatic Index 99.53

Aromaticity 0.0625

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2763.21

LogP -24.89

H-bond Donors 100.0

H-bond Acceptors 95.0

Rotatable Bonds 235.0

Heavy Atoms 474.0

Ring Count 4.0

Amide Bonds 64.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0049130 VERIFIED: YES

Provenance & Taxonomy

OrganismXenopus laevis [Animal]

FamilyMagainin

Tax ID8355

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-MRSA Anti-Candida Anti-Gram-positive Cytolytic Hemolytic

TargetCandida albicans

RECORD: Rec_0069677 VERIFIED: YES