Peptide Database

Peptide NameSLAY-screened peptide P950

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC106H163N27O30S2

DescriptionStandard

        LQTWLFKAESCIIHLSHCET
    

Molecular Weight2359.72 Da

Isoelectric Point (pI)6.00

Net Charge (pH 7.0)-1.08

Net Charge (pH 7.4) -1.42

Charge Density (pH 7.0) -0.0540

GRAVY Index0.27

Hydrophobic Moment 0.37

Boman Index0.20

Instability Index49.04

Aliphatic Index 102.50

Aromaticity 0.1000

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5625.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 914.00

LogP -6.51

H-bond Donors 34.0

H-bond Acceptors 33.0

Rotatable Bonds 76.0

Heavy Atoms 165.0

Ring Count 5.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0266850 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/