Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length419 amino acids

Chemical FormulaC2134H3312N568O599S12

DescriptionStandard

        MMARPYCVVVALLLLAEVSGFKEGASNPGFVARITRKGLEYARRFGVAILKKELSTIKLSDFSGSFKVGWIKSVSYDFYRLKIHCFELRNSDLRLRPRQGVRASLSNNYVFVSGNWKVKKAFITLDGTFDVNVDGISISVSLNLGKDQSGRPTASVSHCHNSIGHISVDISGQLSWILNLFHERIENNFKNILEQKICEMVRKSTTSHLEPYLRTLPVISMIDQVAGIDYSLVGAPQVTSQVLDIPFKGEFFGQNWHSPAPFDAPPIRLPEKHDHMVYFAVSEYVFNTASQVYHQAGRMNFTIQNHHIPGDSPIHLHTSSFRAIIPQLARLYPNMELELETSPASAPFLTFTPGSVTFTPVIDIQVFALLPTSSDRKPLFQLRVVSLISGLHLPLGKPLSPLKEWETDDAGDYFCLPAE
    

Molecular Weight46893.35 Da

Isoelectric Point (pI)8.47

Net Charge (pH 7.0)3.81

Net Charge (pH 7.4) 2.66

Charge Density (pH 7.0) 0.0091

GRAVY Index-0.04

Hydrophobic Moment 0.84

Boman Index0.09

Instability Index34.91

Aliphatic Index 93.96

Aromaticity 0.1026

Extinction Coeff. Reduced 45380.00

Extinction Coeff. Oxidized 45630.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0247414 VERIFIED: NO

Provenance & Taxonomy

OrganismLeptonychotes weddellii (Weddell seal) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria