Peptide Database

Peptide NameKAB1_OLDAF

Function Ontology

Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Neurological / Signaling ▸ Signaling peptide

Other / Curated residual function label ▸ Generic enzyme inhibition annotation

Standard StatusStandard

Sequence Length124 amino acids

Chemical FormulaC582H961N153O174S12

DescriptionStandard

        EATLVTDVAEKMFLRKMKAEAKTSETADQVFLKQLQLKGLPVCGETCVGGMAKFTVCLLLCLLLAAFVGAFGSELSDSHKTTLVNEIAEKMLQRKILDGVTCNTPGCTCSWPVCTRNGLPSLAA
    

Molecular Weight13270.56 Da

Isoelectric Point (pI)7.76

Net Charge (pH 7.0)0.86

Net Charge (pH 7.4) 0.49

Charge Density (pH 7.0) 0.0069

GRAVY Index0.29

Hydrophobic Moment 0.59

Boman Index0.13

Instability Index44.75

Aliphatic Index 95.97

Aromaticity 0.0484

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 6000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5211.20

LogP -51.08

H-bond Donors 187.0

H-bond Acceptors 188.0

Rotatable Bonds 447.0

Heavy Atoms 921.0

Ring Count 12.0

Amide Bonds 130.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0241870 VERIFIED: YES

Provenance & Taxonomy

OrganismOldenlandia affinis [Plant]

FamilyCyclotide

Tax ID60225

Structure & Mods

Confighead-to-tail cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond reported, sites not specified

Bio-Activity Profile

Function

Signaling Enzyme inhibitory ACE inhibitory Antihypertensive

TargetAngiotensin-converting enzyme