Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length354 amino acids

Chemical FormulaC1718H2705N457O513S13

DescriptionStandard

        MKCTAATCRAEMVSVLTLTLTLTLTLSPGTDAADPGFVVRLTQKGLDYARDEGMSVLQQQLAKIHLPDFSGSTHIKHMGTVKYSFDSMAVRSFQLPSSQISLVPGVGLKLTISGAFIQVDGQWKISYIHISTHGGFDLKVEGLSISVGLRLGSDGSGRPSIAPSDCSNHIGDVKVHISGKFGWLVDLFQHNIEKDLRKAIEDQICPLVSESITTKLEPLLQTLPVTAKIDGVAAIDYSLTGTPLVMSEFVDVPLKGEFFNYGNRSAPPFSPPALSFPAEHSLMVYFGASEYLFNTAGYVYQMAGKLSFTITDDMVRGGGRLSGYPVPTRYSESHRGTQIRRSELTAGSRNVQYP
    

Molecular Weight38386.45 Da

Isoelectric Point (pI)6.79

Net Charge (pH 7.0)-0.64

Net Charge (pH 7.4) -1.49

Charge Density (pH 7.0) -0.0018

GRAVY Index-0.02

Hydrophobic Moment 0.74

Boman Index0.11

Instability Index46.40

Aliphatic Index 88.93

Aromaticity 0.0847

Extinction Coeff. Reduced 28880.00

Extinction Coeff. Oxidized 29130.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0349715 VERIFIED: NO

Provenance & Taxonomy

OrganismLeptobrachium leishanense [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence