Peptide Database

Peptide NameSLAY-screened peptide P5794

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC97H140N32O35S

DescriptionStandard

        NSSNKDGYNHSRSYICHSYN
    

Molecular Weight2346.41 Da

Isoelectric Point (pI)8.17

Net Charge (pH 7.0)0.92

Net Charge (pH 7.4) 0.60

Charge Density (pH 7.0) 0.0461

GRAVY Index-1.68

Hydrophobic Moment 0.45

Boman Index-0.34

Instability Index74.62

Aliphatic Index 19.50

Aromaticity 0.1500

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1133.00

LogP -17.68

H-bond Donors 41.0

H-bond Acceptors 39.0

Rotatable Bonds 75.0

Heavy Atoms 165.0

Ring Count 5.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0013127 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/