Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length508 amino acids

Chemical FormulaC2592H4058N650O735S17

DescriptionStandard

        MCTKMVQVLWGCFLLWNLYISSAQTIYPGIKARATRRALDYGIQAGVAMIEQMVKERSIPDLKGSESPEFLKIDYMNYKLINIKINAFSLPNTSLAFVPGVGIRALIKHGTANISTDWEIKSPLFQDTGGANLLLSGVYFTGIVVLARNDFGHPILKLQDCNAQVSHNDISFSGELSVLYNSFAEPMEKAILKNLNKMLCPIITSEVEALNANLSMLEVLRSIDNYTLLDYSLISSPEITENYIDLNLKGVFYPLENLTDPPFSSVPFVLPEHSDSMIYIGISEYFFKSASYAYFTAGAFNVTLTTEKIFNHLIRNSQGLGNMLSWIAELYILSQPFMVQVLAREPPVVNLLPGNFTLDIPASFVILTQSKNSTAETIISMDFVASTNVALAILGQRLICSLSLDRFRLSLPESLRSHIEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPHKISLVNSDIEVLEGFLLISTDLKYKTSLKQQPSFHGWEALNLISGQWRGKPAPW
    

Molecular Weight56630.96 Da

Isoelectric Point (pI)5.90

Net Charge (pH 7.0)-5.71

Net Charge (pH 7.4) -6.57

Charge Density (pH 7.0) -0.0112

GRAVY Index0.19

Hydrophobic Moment 0.75

Boman Index0.18

Instability Index44.16

Aliphatic Index 109.04

Aromaticity 0.1004

Extinction Coeff. Reduced 63830.00

Extinction Coeff. Oxidized 64080.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0291205 VERIFIED: NO

Provenance & Taxonomy

OrganismPhocoena sinus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence