Peptide Database

Peptide NameDN81opt

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC93H135N31O28S3

DescriptionStandard

        RQMRAWGQDYQHGGMGYSC
    

Molecular Weight2231.45 Da

Isoelectric Point (pI)8.21

Net Charge (pH 7.0)0.84

Net Charge (pH 7.4) 0.56

Charge Density (pH 7.0) 0.0440

GRAVY Index-1.26

Hydrophobic Moment 0.57

Boman Index-0.19

Instability Index34.05

Aliphatic Index 5.26

Aromaticity 0.1579

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 982.65

LogP -11.52

H-bond Donors 36.0

H-bond Acceptors 33.0

Rotatable Bonds 72.0

Heavy Atoms 155.0

Ring Count 5.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0389363 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetDENV-2

RECORD: Rec_0398341 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-DENV Entry inhibition

TargetDengue 2 virus(DENV-2) | LLC-MK2 cells

Activity36±6 μM

MethodIC50

Half-LifeMammalian: 1 h; Yeast: 2 min; E. coli: 2 min

PaperStructural optimization and de novo design of dengue virus entry inhibitory peptides. | Costin JM, Jenwitheesuk E, Lok SM, Hunsperger E, Conrads KA, Fontaine KA, Rees CR, Rossmann MG, Isern S, Samudrala R, Michael SF. | PLoS Negl Trop Dis. 2010 Jun 22;4(6):e721. | DOI:10.1371/journal.pntd.0000721 | PMID:20582308 PMID20582308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20582308/

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