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MYP_103168
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Basic Information
DN81opt
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Standard
19 amino acids
C93H135N31O28S3
Standard
Sequence
RQMRAWGQDYQHGGMGYSC
Physicochemical Analysis
2231.45 Da
8.21
0.84
0.56
0.0440
-1.26
0.57
-0.19
34.05
5.26
0.1579
8480.00
8480.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
982.65
-11.52
36.0
33.0
72.0
155.0
5.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0076008 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
dengue 2 virus(DENV-2):inhibition of virus infection in LLC-MK2 cells
36±6 μM
IC50
PaperPubMed PMID: 20582308 PMID20582308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20582308/
RECORD: Rec_0271822 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
DENV-2
50-60 % Inhibition
Inhibition
PMID20582308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20582308/
RECORD: Rec_0324853 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 20582308 PMID20582308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20582308/
RECORD: Rec_0356353 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 21.1%, E 10.5%, T 47.4%, C 21.1% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0369068 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Dengue 2 virus (Virus entry); LLC-MK2
36 μM
Focus reduction assay
PaperStructural optimization and de novo design of dengue virus entry inhibitory peptides. | Costin JM, Jenwitheesuk E, Lok SM, Hunsperger E, Conrads KA, Fontaine KA, Rees CR, Rossmann MG, Isern S, Samudrala R, Michael SF. | PLoS Negl Trop Dis. 2010 | PMID:20582308 PMID20582308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20582308/
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