Peptide Database

Peptide NameSargramostim

Function Ontology

Anticancer

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length127 amino acids

Chemical FormulaC639H1006N168O196S8

DescriptionStandard

        APARSPSPSTQPWEHVNAIQEALRLLNLSRDTAAEMNETVEVISEMFDLQEPTCLQTRLELYKQGLRGSLTKLKGPLTMMASHYKQHCPPTPETSCATQIITFESFKENLKDFLLVIPFDCWEPVQE
    

Molecular Weight14434.35 Da

Isoelectric Point (pI)5.05

Net Charge (pH 7.0)-5.94

Net Charge (pH 7.4) -6.38

Charge Density (pH 7.0) -0.0468

GRAVY Index-0.38

Hydrophobic Moment 0.73

Boman Index-0.00

Instability Index63.87

Aliphatic Index 79.13

Aromaticity 0.0709

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14230.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5812.71

LogP -55.53

H-bond Donors 198.0

H-bond Acceptors 201.0

Rotatable Bonds 470.0

Heavy Atoms 1011.0

Ring Count 25.0

Amide Bonds 138.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0151235 VERIFIED: YES

Provenance & Taxonomy

OrganismSaccharomyces cerevisiae [Fungus]

FamilyGM-CSF

Tax ID4932

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hematopoietic GM-CSF Myeloid recovery

PaperPubMed-linked source references: PMID:25416452; PMID:25270293; PMID:15583528; PMID:27838641; PMID:27783330; PMID:27576783; PMID:27619199; PMID:27141384 PMID25416452;25270293;15583528;27838641;27783330;27576783;27619199;27141384 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25416452/ PatentCA1341150

RECORD: Rec_0233238 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Saccharomyces cerevisiae [Fungus]

FamilyInterleukin

Tax ID9606; 4932

Structure & Mods

Configsingle-chain therapeutic peptide/protein [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer Immunomodulatory

RECORD: Rec_0238852 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Saccharomyces cerevisiae [Fungus]

FamilyGrowth factor

Tax ID9606; 4932

Structure & Mods

Configsingle-chain therapeutic peptide/protein [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer Immunomodulatory Enzyme replacement