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MYP_103055
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Basic Information
Tyrocidine A, TA
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
10 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
FPFFNQYVXL
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0173567 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]; Bacillus aneurinolyticus [Bacterium]; Bacillus brevis [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 9
Bio-Activity Profile
Anticancer Cytotoxic
Human lung carcinoma A549
14.0 μM
LC50
PMID24752256;17462586;27328781;19586775 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24752256/
RECORD: Rec_0181660 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]; Bacillus aneurinolyticus [Bacterium]; Bacillus brevis [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 9
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Staphylococcus aureus ATCC 33592
32.0 μg/mL
MIC
PMID24752256;17462586;27328781;19586775 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24752256/
RECORD: Rec_0182101 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]; Bacillus aneurinolyticus [Bacterium]; Bacillus brevis [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 9
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Listeria monocytogenes B73-MR1
16.0
MIC
PMID24752256;17462586;27328781;19586775 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24752256/
RECORD: Rec_0187330 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]; Bacillus aneurinolyticus [Bacterium]; Bacillus brevis [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 9
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Staphylococcus epidermidis MRL 19010
16.0 μg/mL
MIC
PMID24752256;17462586;27328781;19586775 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24752256/
RECORD: Rec_0197009 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PMID29140694 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29140694/
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