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MYP_103049
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Basic Information
Hymenochirin-1B
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
29 amino acids
C139H251N37O37S
Standard
Sequence
IKLSPETKDNLKKVLKGAIKGAIAVAKMV
Physicochemical Analysis
3064.77 Da
10.13
4.76
4.54
0.1640
0.17
0.69
0.06
12.77
124.48
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1209.62
-8.69
41.0
43.0
111.0
214.0
1.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0169328 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Hymenochirin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓧ (position: 18 and 22) in sequence indicate (S)-N-Fmoc-2-(4'-pentenyl)alanine. Ⓧ (18) and Ⓧ (22) are cross-linked by ring-closing metathesis through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Anticancer
HCT116
4.16±0.21 μM
IC50
PaperYulei Li, Yihan Zhang, Minghao Wu, Qi Chang, Honggang Hu, Xia Zhao. Improving Selectivity, Proteolytic Stability, and Antitumor Activity of Hymenochirin-1B: A Novel Glycosylated Staple Strategy. ACS Chem Biol. 2019 Mar 15;14(3):516-525. doi: 10.1021/acschembio.9b00046. Epub 2019 Mar 1. PMID30789695 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30789695/
RECORD: Rec_0175201 VERIFIED: NO
Provenance & Taxonomy
Hymenochirus boettgeri [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
maltophilia
6.25 μM
MIC
RECORD: Rec_0177827 VERIFIED: NO
Provenance & Taxonomy
Hymenochirus boettgeri [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 25923
12.5 μM
MIC
RECORD: Rec_0180591 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Hymenochirin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓧ (position: 6 and 10) in sequence indicate (S)-N-Fmoc-2-(4'-pentenyl)alanine. Ⓧ (6) and Ⓧ (10) are cross-linked by ring-closing metathesis through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Anticancer
HepG2
1.60±0.24 μM
IC50
PaperYulei Li, Yihan Zhang, Minghao Wu, Qi Chang, Honggang Hu, Xia Zhao. Improving Selectivity, Proteolytic Stability, and Antitumor Activity of Hymenochirin-1B: A Novel Glycosylated Staple Strategy. ACS Chem Biol. 2019 Mar 15;14(3):516-525. doi: 10.1021/acschembio.9b00046. Epub 2019 Mar 1. PMID30789695 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30789695/
RECORD: Rec_0184359 VERIFIED: YES
Provenance & Taxonomy
Congo dwarf clawed [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
such as Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae
20-40 μM
MIC
PaperThe hymenochirins: A family of host-defense peptides from the Congo dwarf clawed frog Hymenochirus boettgeri (Pipidae).
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