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MYP_103049
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Basic Information
Hymenochirin-1B
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
29 amino acids
C139H251N37O37S
Standard
Sequence
IKLSPETKDNLKKVLKGAIKGAIAVAKMV
Physicochemical Analysis
3064.77 Da
10.13
4.76
4.54
0.1640
0.17
0.69
0.06
12.77
124.48
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1209.62
-8.69
41.0
43.0
111.0
214.0
1.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0357960 VERIFIED: YES
Provenance & Taxonomy
Hymenochirus boettgeri [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
L. salivarius FortaFit Ls-33 [
250 μg/mL
MIC
PMID31102497 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31102497/
RECORD: Rec_0358089 VERIFIED: YES
Provenance & Taxonomy
Hymenochirus boettgeri [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
L. casei Shirota [
64 μg/mL
MBC
PMID31102497 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31102497/
RECORD: Rec_0376780 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
C-terminal amide reported in activity study
Bio-Activity Profile
Antimicrobial Anticancer
A549
2.5±0.2 μM
LC50
PaperAntimicrobial and anticancer peptides from the skin secretion of the Madagascan hylid frog Boophis luteus PMID24185042;30789695 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24185042/
RECORD: Rec_0380381 VERIFIED: NO
Provenance & Taxonomy
Hymenochirus boettgeri [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus epidermidis RP62A
3.1 μM
MIC
RECORD: Rec_0384813 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Hymenochirin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓧ (position: 18 and 22) in sequence indicate (S)-N-Fmoc-2-(4'-pentenyl)alanine. Ⓧ (18) and Ⓧ (22) are cross-linked by ring-closing metathesis through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Anticancer
A549
7.35±0.22 μM
IC50
PaperYulei Li, Yihan Zhang, Minghao Wu, Qi Chang, Honggang Hu, Xia Zhao. Improving Selectivity, Proteolytic Stability, and Antitumor Activity of Hymenochirin-1B: A Novel Glycosylated Staple Strategy. ACS Chem Biol. 2019 Mar 15;14(3):516-525. doi: 10.1021/acschembio.9b00046. Epub 2019 Mar 1. PMID30789695 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30789695/
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