Peptide Database

Peptide NameE-2078 [N-methyl-Tyr1, N-methyl-Arg7-D-Leu8] Dyn A (1–8) ethylamide]

Function Ontology

Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic

Standard StatusStandard

Sequence Length8 amino acids

Chemical FormulaC46H72N14O10

DescriptionStandard

        YGGFLRRL
    

Molecular Weight981.15 Da

Isoelectric Point (pI)10.84

Net Charge (pH 7.0)1.76

Net Charge (pH 7.4) 1.55

Charge Density (pH 7.0) 0.2199

GRAVY Index-0.09

Hydrophobic Moment 0.67

Boman Index-0.07

Instability Index109.24

Aliphatic Index 97.50

Aromaticity 0.2500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 411.05

LogP -2.14

H-bond Donors 16.0

H-bond Acceptors 12.0

Rotatable Bonds 31.0

Heavy Atoms 70.0

Ring Count 2.0

Amide Bonds 7.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0365251 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyDynorphin

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

N-TermMethylation

C-TermAmidation

Other ModsMethylation on Arg7 and Tyr1

Bio-Activity Profile

Function

Analgesic

MethodMALDI-MS

Half-LifeRhesus monkey blood plasma (Intravenous), in vivo; 2640 s