Peptide Database

Peptide NameSLAY-screened peptide P2053

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC106H172N32O33S2

DescriptionStandard

        DIQIDRTHHNFKITLTLTCCN
    

Molecular Weight2486.82 Da

Isoelectric Point (pI)6.90

Net Charge (pH 7.0)-0.08

Net Charge (pH 7.4) -0.42

Charge Density (pH 7.0) -0.0040

GRAVY Index-0.30

Hydrophobic Moment 0.37

Boman Index-0.06

Instability Index-1.15

Aliphatic Index 92.86

Aromaticity 0.0476

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1075.39

LogP -11.76

H-bond Donors 39.0

H-bond Acceptors 37.0

Rotatable Bonds 82.0

Heavy Atoms 173.0

Ring Count 3.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0358338 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/