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MYP_102830
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Basic Information
Brevinin-2RTb
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
33 amino acids
C147H255N39O46S2
Standard
Sequence
GILDTLKEFGKTAAKGIAQSLLSTASCKLAKTC
Physicochemical Analysis
3368.96 Da
9.24
2.74
2.50
0.0830
0.25
0.66
0.11
18.74
97.88
0.0303
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1383.92
-15.92
51.0
51.0
118.0
234.0
1.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0343957 VERIFIED: YES
Provenance & Taxonomy
Amolops ricketti [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Rhodococcus rhodochrous X15
12.5 μg/mL
MIC
PMID22100518 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22100518/
RECORD: Rec_0379687 VERIFIED: YES
Provenance & Taxonomy
Amolops ricketti [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
stereochemistry not specified [Other]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus licheniformis X39
200 μg/mL
MIC
PMID22100518 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22100518/
RECORD: Rec_0384490 VERIFIED: YES
Provenance & Taxonomy
Amolops ricketti [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0392904 VERIFIED: YES
Provenance & Taxonomy
Amolops ricketti [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
14.84 μM
MIC
PaperH. Wang et al. / Peptides 33 (2012) 27-34. Identification and characterization of antimicrobial peptides from skin of Amolops ricketti (Anura: Ranidae) Evidence URLhttps://www.uniprot.org/uniprotkb/D1MIZ8/entry
RECORD: Rec_0397971 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 57.6%, E 0.0%, T 30.3%, C 12.1% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Anti-Gram-positive Anti-Gram-negative
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
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