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MYP_102819
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Basic Information
E2EM15W-S2
Antimicrobial
Antimicrobial ▸ Antibacterial
Standard
15 amino acids
C81H131N21O20
Standard
Sequence
TLKQFAKGWGKDLVK
Physicochemical Analysis
1719.04 Da
10.00
2.40
2.20
0.1597
-0.57
0.65
-0.07
2.48
78.00
0.1333
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
691.21
-4.18
24.0
23.0
60.0
122.0
3.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0284951 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Esculentin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The Ⓧ (position: 6 and 10) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (6) and Ⓧ (10) are cross-linked by hydrocarbon stapling through an oct-4-enyl staple
Bio-Activity Profile
Antimicrobial Antibacterial
Klebsiella pneumonia
50 μg/mL
MIC
PaperThanh Kim Pham, Do-Hee Kim, Bong-Jin Lee, Young-Woo Kim. Truncated and constrained helical analogs of antimicrobial esculentin-2EM. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6717-20. Epub 2013 Oct 26. PMID24211019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24211019/
RECORD: Rec_0366954 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Esculentin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The Ⓧ (position: 6 and 10) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (6) and Ⓧ (10) are cross-linked by hydrocarbon stapling through an oct-4-enyl staple
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus
6.25 μg/mL
MIC
PaperThanh Kim Pham, Do-Hee Kim, Bong-Jin Lee, Young-Woo Kim. Truncated and constrained helical analogs of antimicrobial esculentin-2EM. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6717-20. Epub 2013 Oct 26. PMID24211019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24211019/
RECORD: Rec_0371694 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Esculentin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The Ⓧ (position: 6 and 10) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (6) and Ⓧ (10) are cross-linked by hydrocarbon stapling through an oct-4-enyl staple
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus subtilis
6.25 μg/mL
MIC
PaperThanh Kim Pham, Do-Hee Kim, Bong-Jin Lee, Young-Woo Kim. Truncated and constrained helical analogs of antimicrobial esculentin-2EM. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6717-20. Epub 2013 Oct 26. PMID24211019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24211019/
RECORD: Rec_0416274 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Esculentin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The Ⓧ (position: 6 and 10) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (6) and Ⓧ (10) are cross-linked by hydrocarbon stapling through an oct-4-enyl staple
Bio-Activity Profile
Antimicrobial Antibacterial
Shigella dysenteriae
50 μg/mL
MIC
PaperThanh Kim Pham, Do-Hee Kim, Bong-Jin Lee, Young-Woo Kim. Truncated and constrained helical analogs of antimicrobial esculentin-2EM. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6717-20. Epub 2013 Oct 26. PMID24211019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24211019/
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