Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length408 amino acids

Chemical FormulaC2080H3223N537O557S16

DescriptionStandard

        MSNLYLTMMIWVLFLPIFEAHLFLKKEPKPPGALKLQITKRGLDYAKTHPNQTTSGEGLEGFFCKRQGSQTGHPKCSDCVHWQLGVKTFIWTNIVLRSLLVFLGLDVDDGGRPLVRLLSCLADVLDFEVCVGVEKSIDQFSNNLRNTKFWVQIDPIAGFNYSLVSKPQIAEDRCNLDFKGEFFLMGGHQRSPLVPSPLVLPKRSSSMVVIGISDVLVNSAAFVYFSGNMLQVKYTDKTLKRQFPEMPMELHLAAQKEPKLHFHPGGLDAIVLGRAEAFVVLPNSSLVHVFTLNVDCNFTGQIFLEGVHSGHSFAKVGGSVALKGFLILGYFSPFLVQLSPLETLLKIAGQVALSVHNLKLRAGKLLPAFYGASLMGPEVSVHEVSTWARGRWAPWASSPPATPFSQYF
    

Molecular Weight45177.14 Da

Isoelectric Point (pI)8.96

Net Charge (pH 7.0)7.59

Net Charge (pH 7.4) 6.53

Charge Density (pH 7.0) 0.0186

GRAVY Index0.15

Hydrophobic Moment 0.81

Boman Index0.17

Instability Index33.42

Aliphatic Index 97.43

Aromaticity 0.1078

Extinction Coeff. Reduced 50420.00

Extinction Coeff. Oxidized 50795.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0353761 VERIFIED: NO

Provenance & Taxonomy

OrganismOphiophagus hannah [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence