Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length419 amino acids

Chemical FormulaC2129H3332N568O595S12

DescriptionStandard

        AHQHGIAFLEKELAQLKLRDMSGDFRIRHMGKVHYELSELDLHSFHLPYSRISLVPNTGLQVSISNAFAEVDGDWRVKFYFMRDHGSFDFKVENVYIKINLRLGSDAEGKPTIETADCSTRISKVRVHFSGKLGWLYNLFYNAVEPTFRRILEDKVCETVARSVRRELQPYARTLPVTARIGDKVGIDYSLVASPTATAQSLDTGLKGEFFSLAQRSAVPFPPLALALPPDHNRMVYFGASSYFFNTAAFAYHAAGVLVFEITDAKIPKEADFHLNTTTFSAFIPQLEEMYPDMPMKIRLSAPSAPFLNIGPEGLTLRPVVDIQAYAILPSSKLAPLFLLSLVSNVSAVINVKSGHIVGSLQVGRMKLSLKHSDVGTFQVRMLQSIMNIYASSILLPRLNERLAEGFPLPLPDRIQLSN
    

Molecular Weight46789.46 Da

Isoelectric Point (pI)8.86

Net Charge (pH 7.0)4.95

Net Charge (pH 7.4) 3.98

Charge Density (pH 7.0) 0.0118

GRAVY Index0.01

Hydrophobic Moment 0.84

Boman Index0.09

Instability Index40.93

Aliphatic Index 97.06

Aromaticity 0.1002

Extinction Coeff. Reduced 31860.00

Extinction Coeff. Oxidized 31985.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0389617 VERIFIED: NO

Provenance & Taxonomy

OrganismBuceros rhinoceros silvestris [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria