Peptide Database

Peptide NamePyrokinin-1

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length49 amino acids

Chemical FormulaC221H341N69O71S5

DescriptionStandard

        QYDGRGSDMVEGPRVERMHPETSGGCVGAHCLTQNSEGPVGAMWFGPRL
    

Molecular Weight5260.82 Da

Isoelectric Point (pI)5.44

Net Charge (pH 7.0)-2.07

Net Charge (pH 7.4) -2.42

Charge Density (pH 7.0) -0.0423

GRAVY Index-0.62

Hydrophobic Moment 0.48

Boman Index-0.03

Instability Index25.50

Aliphatic Index 43.67

Aromaticity 0.0612

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7115.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2220.16

LogP -27.30

H-bond Donors 78.0

H-bond Acceptors 76.0

Rotatable Bonds 167.0

Heavy Atoms 366.0

Ring Count 10.0

Amide Bonds 51.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0084124 VERIFIED: YES

Provenance & Taxonomy

OrganismNasonia vitripennis [Animal]

FamilyPyrokinin

Tax ID7425

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPyroglutamate

C-TermAmidation

Bio-Activity Profile

Function

Neuropeptide Invertebrate neurohormone

RECORD: Rec_0124210 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyPyrokinin/PBAN

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0382664 VERIFIED: YES

Provenance & Taxonomy

OrganismNasonia vitripennis [Animal]

FamilyPyrokinin

Tax ID7425

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour