Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length654 amino acids

Chemical FormulaC3219H5053N877O909S18

DescriptionStandard

        MPGSPPRPRGFGGSGGQNMAREPDKALTRATLVVLATLGTAVIATTNPGVVARITQKGLDYACQQGVAVLQKELEKITIPTFSGSFKIKHLGKGHYSFHSMAIRGFQLPVSQIKLAPSEGLDLSIANANVKISGKWKARKNFIKTSGNFDLSVEGVSISAVLKLGFDPASGHCTVSCSRCNNHINSVRVHISGSSLGWLINLFHEKMESSLRNRMTGEICKVVTSSVSSKLQRYLETMPVTTRIDHVAGINYSLVAPPTATTDSLDGQLKGEFFRWGHPSPPPFAPPPLAFPSDHDRMVYLGISNYFFNTAGFVYQQAGVLNLTVTDNVIPKESKFRLTTDVFGILIPQVAKMFPNMKVQLVFWASSPPHLTVHPEGLVLTPTLDAQAFAVLPNSSLAPLFVLRLSMNISVTVGATPDRLVGQLSLNSPPAVSTESPAPWTAPPSWADAWLGDASWCLQPALSHGSAQPPASLIRLSARKTHSDFLLPHPWDFVSRLVLEEPQQRRLWLSAGSGVEAARPQSAAHLANTELTKVLLPWLQKRPSDLEETNKLLLELKHSDIGPFSVEVLQALMNYVVPIAVIPKVNERLQEGFPLPMPNNVQLFNLVLQSHQPDPRQHLRLLGDAFFSSKAPSPNFPAASHGNFLLFGADVRYG
    

Molecular Weight71160.06 Da

Isoelectric Point (pI)9.34

Net Charge (pH 7.0)13.24

Net Charge (pH 7.4) 11.81

Charge Density (pH 7.0) 0.0202

GRAVY Index-0.04

Hydrophobic Moment 0.71

Boman Index0.11

Instability Index45.79

Aliphatic Index 91.54

Aromaticity 0.0795

Extinction Coeff. Reduced 73910.00

Extinction Coeff. Oxidized 74285.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0109949 VERIFIED: YES

Provenance & Taxonomy

OrganismFelis catus [Animal]

FamilyBPI/LBP

Tax ID9685

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria