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MYP_102590
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
50 amino acids
C254H410N82O74S6
Standard
Sequence
EFELDRICGYGTARCRKKCRSQEYRIGRCPNTYACCLRKWDESLLNRTKP
Physicochemical Analysis
5988.87 Da
9.27
5.78
5.51
0.1156
-1.01
0.58
-0.39
42.03
50.80
0.1000
9970.00
10345.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2601.62
-28.06
101.0
86.0
201.0
416.0
8.0
52.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0059123 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
8-36, 15-29, 19-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli BL21
100 μg/mL
MIC
PMID11481241 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11481241/
RECORD: Rec_0109403 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
8-36, 15-29, 19-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Saccharomyces cerevisiae ATCC9763
100 μg/mL
MIC
PMID11481241 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11481241/
RECORD: Rec_0164353 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
8-35; 15-29; 19-36
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0284659 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Like hBD2 and hBD3, the expression of hBD4 can be induced
Bio-Activity Profile
Antimicrobial
Escherichia coli ATCC 25922, Enterococcus faecalis. Antimicrobial robustness: Activity is salt-sensitive. The S-S bridges are not needed for antibacterial activity. Structure: Crystal structure reveals an usual conformation at the N-terminus, explaining why hBD4 does not induce CCR6-mediated chemotaxis (Prahl A et al., 2017). Recombinant production: Genetic modification was used to ectopically express human beta defensin 4 in cultured primary epidermal keratinocytes (Smiley et al., 2007). Resistance mechanism: In HEK293 cells, Mycobacterium tuberculosis uses dehydrogenating L-alanine to suppress this AMP expression (Peng et al., 2024). Updated 3/2017; 3/2018; 3/2023; 5/2024
PaperHuman beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity
RECORD: Rec_0335261 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]; Pan troglodytes [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
8-35; 15-29; 19-36
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus carnosis, Escherichia coli, Saccharomyces cerevisiae, TM300, BL21, ATCC9763
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