Peptide Database

Peptide NameBMP-8A

Function Ontology

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length139 amino acids

Chemical FormulaC686H1083N207O194S11

DescriptionStandard

        AVRPLRRRQPKKSNELPQANRLPGIFDDVRGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMKPNAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH
    

Molecular Weight15686.92 Da

Isoelectric Point (pI)9.24

Net Charge (pH 7.0)8.24

Net Charge (pH 7.4) 7.61

Charge Density (pH 7.0) 0.0593

GRAVY Index-0.36

Hydrophobic Moment 0.58

Boman Index-0.07

Instability Index73.73

Aliphatic Index 78.56

Aromaticity 0.0791

Extinction Coeff. Reduced 19940.00

Extinction Coeff. Oxidized 20440.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6447.57

LogP -67.39

H-bond Donors 231.0

H-bond Acceptors 219.0

Rotatable Bonds 508.0

Heavy Atoms 1098.0

Ring Count 28.0

Amide Bonds 152.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0208989 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsThe active peptide is a homodimer linked by a disulphide bond between cysteine residues at position 103 of each chain. Predicted N-linked glycososylation of asparagine residue at position 80. Predicted disulphide bond formation between cysteine residues at positions 38 and 101, 67 and 136, and 71 and 138

Bio-Activity Profile

Function

Receptor agonist Immunomodulatory Signaling peptide

TargetBone morphogenetic protein receptors (Human)