Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length258 amino acids

Chemical FormulaC1308H2063N331O379S8

DescriptionStandard

        MKARPYCVVVVLLLLTGLSEFGEGTSNPGLTTRITKKSLKYAIQYAVTTLKKELSTIRLPDISGSSEISWVGWVSYDFYSLKIYHFNLQNWDLSLLPELGIRVSLSSNYMSIGGNWKVNKAFITLQGTFDMKVYGISISVSLNLGKDQSGHPTSLVTQCSNSIGHVSIDISGSLSWILNLFHEIIENNIKMVLEQKEPISIRLRMEQDLVENQGCSLFSHKLSAPWTLVTKEPVTSGHLATALYQTSSFFFIVVLSLN
    

Molecular Weight28745.88 Da

Isoelectric Point (pI)8.35

Net Charge (pH 7.0)2.01

Net Charge (pH 7.4) 1.39

Charge Density (pH 7.0) 0.0078

GRAVY Index0.14

Hydrophobic Moment 0.65

Boman Index0.16

Instability Index32.72

Aliphatic Index 107.21

Aromaticity 0.0969

Extinction Coeff. Reduced 46410.00

Extinction Coeff. Oxidized 46535.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0385187 VERIFIED: NO

Provenance & Taxonomy

OrganismHeterocephalus glaber [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence