Peptide Database

Peptide NameSLAY-screened peptide P4611

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC59H89N15O21

DescriptionStandard

        TDAVRVFSFTSD
    

Molecular Weight1344.43 Da

Isoelectric Point (pI)4.53

Net Charge (pH 7.0)-1.60

Net Charge (pH 7.4) -1.79

Charge Density (pH 7.0) -0.1330

GRAVY Index0.11

Hydrophobic Moment 0.45

Boman Index0.03

Instability Index9.17

Aliphatic Index 56.67

Aromaticity 0.1667

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 600.84

LogP -7.49

H-bond Donors 22.0

H-bond Acceptors 20.0

Rotatable Bonds 41.0

Heavy Atoms 95.0

Ring Count 2.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0038686 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/