Peptide Database

Peptide NameEtanercept

Function Ontology

Anticancer

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Standard StatusStandard

Sequence Length467 amino acids

Chemical FormulaC2224H3472N618O701S36

DescriptionStandard

        LPAQVAFTPYAPEPGSTCRLREYYDQTAQMCCSKCSPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSSDQVETQACTREQNRICTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVARPGTETSDVVCKPCAPGTFSNTTSSTDICRPHQICNVVAIPGNASMDAVCTSTSPTRSMAPGAVHLPQPVSTRSQHTQPTPEPSTAPSTSFLLPMGPSPPAEGSTGDEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
    

Molecular Weight51237.42 Da

Isoelectric Point (pI)7.15

Net Charge (pH 7.0)0.49

Net Charge (pH 7.4) -0.81

Charge Density (pH 7.0) 0.0010

GRAVY Index-0.53

Hydrophobic Moment 0.56

Boman Index-0.05

Instability Index56.48

Aliphatic Index 56.72

Aromaticity 0.0707

Extinction Coeff. Reduced 59360.00

Extinction Coeff. Oxidized 61110.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0276458 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Chinese hamster ovary cell line [Animal]

FamilyMonoclonal antibody

Tax ID9606; 10029

Structure & Mods

Configsingle-chain therapeutic peptide/protein [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer Immunomodulatory

TargetCHO

Half-Life70.7-94.8 hours in pediatric JIA patients