Peptide Database

Peptide Namedefensin HANP-4

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length33 amino acids

Chemical FormulaC161H255N49O47S6

DescriptionStandard

        VTCFCKRPVCDSGETQIGYCRLGNTFYRLCCRQ
    

Molecular Weight3821.44 Da

Isoelectric Point (pI)8.67

Net Charge (pH 7.0)2.68

Net Charge (pH 7.4) 2.37

Charge Density (pH 7.0) 0.0811

GRAVY Index-0.20

Hydrophobic Moment 0.73

Boman Index-0.13

Instability Index42.39

Aliphatic Index 53.03

Aromaticity 0.1212

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1584.60

LogP -18.21

H-bond Donors 63.0

H-bond Acceptors 56.0

Rotatable Bonds 123.0

Heavy Atoms 263.0

Ring Count 5.0

Amide Bonds 35.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0399298 VERIFIED: YES

Provenance & Taxonomy

OrganismMesocricetus auratus [Animal]

FamilyDefensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

Other ModsIt contains three disulfide bonds: 3,31; 5,20; 10,30

Bio-Activity Profile

Function

Antimicrobial Antifungal

TargetCandida albicans

Activity81.7 μg/mL

MethodIC50

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