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MYP_102318
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Basic Information
defensin HANP-4
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
33 amino acids
C161H255N49O47S6
Standard
Sequence
VTCFCKRPVCDSGETQIGYCRLGNTFYRLCCRQ
Physicochemical Analysis
3821.44 Da
8.67
2.68
2.37
0.0811
-0.20
0.73
-0.13
42.39
53.03
0.1212
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1584.60
-18.21
63.0
56.0
123.0
263.0
5.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0136755 VERIFIED: YES
Provenance & Taxonomy
Mesocricetus auratus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
It contains three disulfide bonds: 3,31; 5,20; 10,30
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli
11.8 μg/mL
IC50
PaperIsolation, antimicrobial activities, and primary structures of hamster neutrophil defensins.
RECORD: Rec_0156717 VERIFIED: YES
Provenance & Taxonomy
Mesocricetus auratus [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-31; 5-20; 10-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Pseudomonas aeruginosa
PaperPubMed PMID: 8890190 PMID8890190 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8890190/
RECORD: Rec_0157756 VERIFIED: YES
Provenance & Taxonomy
Mesocricetus auratus [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-31; 5-20; 10-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli
PaperPubMed PMID: 8890190 PMID8890190 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8890190/
RECORD: Rec_0182838 VERIFIED: YES
Provenance & Taxonomy
Mesocricetus auratus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
It contains three disulfide bonds: 3,31; 5,20; 10,30
Bio-Activity Profile
Antimicrobial Antifungal
Pseudomonas aeruginosa
32.7 μg/mL
IC50
PaperIsolation, antimicrobial activities, and primary structures of hamster neutrophil defensins.
RECORD: Rec_0194747 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 57.6%, T 18.2%, C 24.2% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Antifungal Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
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