Peptide Database

Peptide NameSecretogranin-1

Function Ontology

Hormonal / Endocrine ▸ Secretory pathway peptide ▸ Secretory granule peptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide precursor

Standard StatusStandard

Sequence Length626 amino acids

Chemical FormulaC3041H4753N949O1039S8

DescriptionStandard

        MPVDIRNHNEEVVTHCIIEVLSNALLKSSAPPITPECRQVLKKNGKELKNEEKSENENTRFEVRLLRDPADTSEAPGLSSREDSGEGDAQVPTVADTESGGHSRERAGEPPGSQVAKEAKTRYSKSEGQNREEEMVKYQKRERGEVGSEERLSEGPGKAQTAFLNQRNQTPAKKEELVSRYDTQSARGLEKSHSRERSSQESGEETKSQENWPQELQRHPEGQEAPGESEEDASPEVDKRHSRPRHHHGRSRPDRSSQEGNPPLEEESHVGTGNSDEEKARHPAHFRALEEGAEYGEEVRRHSAAQAPGDLQGARFGGRGRGEHQALRRPSEESLEQENKRHGLSPDLNMAQGYSEESEEERGPAPGPSYRARGGEAAAYSTLGQTDEKRFLGETHHRVQESQRDKARRRLPGELRNYLDYGEEKGEEAARGKWQPQGDPRDADENREEARLRGKQYAPHHITEKRLGELLNPFYDPSQWKSSRFERKDPMDDSFLEGEEENGLTLNEKNFFPEYNYDWWEKKPFEEDVNWGYEKRNPVPKLDLKRQYDRVAELDQLLHYRKKSAEFPDFYDSEEQMSPQHTAENEEEKAGQGVLTEEEEKELENLAAMDLELQKIAEKFSGTRRG
    

Molecular Weight71487.53 Da

Isoelectric Point (pI)5.19

Net Charge (pH 7.0)-34.42

Net Charge (pH 7.4) -36.01

Charge Density (pH 7.0) -0.0550

GRAVY Index-1.47

Hydrophobic Moment 0.73

Boman Index-0.35

Instability Index67.53

Aliphatic Index 46.04

Aromaticity 0.0591

Extinction Coeff. Reduced 58330.00

Extinction Coeff. Oxidized 58455.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0292813 VERIFIED: NO

Provenance & Taxonomy

OrganismBos taurus [Animal]

FamilyChromogranin/secretogranin

Tax ID9913

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsSer54 Phosphoserine; Thr59 Phosphothreonine; Thr72 Phosphothreonine; Ser79 Phosphoserine; Ser80 Phosphoserine; Ser84 Phosphoserine; Ser126 Phosphoserine; Ser148 Phosphoserine; Ser256 Phosphoserine; Ser257 Phosphoserine; Ser275 Phosphoserine; Tyr295 Sulfotyrosine; Ser331 Phosphoserine; Ser334 Phosphoserine; Ser355 Phosphoserine; Ser358 Phosphoserine; Tyr418 Sulfotyrosine; Tyr421 Sulfotyrosine; Gln456 Pyroglutamylation; Ser482 Phosphoserine; Ser483 Phosphoserine; Ser494 Phosphoserine; Tyr515 Sulfotyrosine; Tyr517 Sulfotyrosine; Gln547 Pyroglutamylation; Ser564 Phosphoserine; Tyr571 Sulfotyrosine; Ser573 Phosphoserine; Ser578 Phosphoserine; Gln614 Pyroglutamylation

Bio-Activity Profile

Function

Secretory granule peptide Neuropeptide precursor