Peptide Database

Peptide NameDefensin-A (DefA) (GmDefA)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antiparasitic ▸ Antiprotozoal

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length87 amino acids

Chemical FormulaC416H675N115O128S8

DescriptionStandard

        MKFYLVLAFLTLCAVAVTALPAGDETRIDLETLEEDLRLVDGAQVTGELKRDKRVTCNIGEWVCVAHCNSKSKKSGYCSRGVCYCTN
    

Molecular Weight9592.02 Da

Isoelectric Point (pI)6.54

Net Charge (pH 7.0)-0.47

Net Charge (pH 7.4) -0.86

Charge Density (pH 7.0) -0.0054

GRAVY Index0.04

Hydrophobic Moment 0.61

Boman Index0.02

Instability Index25.36

Aliphatic Index 91.84

Aromaticity 0.0690

Extinction Coeff. Reduced 9970.00

Extinction Coeff. Oxidized 10345.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3933.10

LogP -39.56

H-bond Donors 146.0

H-bond Acceptors 137.0

Rotatable Bonds 321.0

Heavy Atoms 667.0

Ring Count 9.0

Amide Bonds 90.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0367199 VERIFIED: YES

Provenance & Taxonomy

OrganismGlossina morsitans morsitans [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Anti-Gram-positive Non-hemolytic Antibacterial Anti-Gram-negative Antiprotozoal

TargetGram-positive and Gram-negative bacteria