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MYP_102182
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Basic Information
Buforin IIb
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
21 amino acids
C115H207N43O23
Standard
Sequence
RAGLQFPVGRLLRRLLRRLLR
Physicochemical Analysis
2560.15 Da
12.00
6.76
6.56
0.3219
-0.10
1.11
-0.34
117.82
148.57
0.0476
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1112.92
-7.79
43.0
30.0
88.0
181.0
2.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0307187 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Histone H2A-derived peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial
MOLT-4
17 μg/mL
IC50
PaperMechanism of anticancer activity of buforin IIb, a histone H2A-derived peptide PMID18617323 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18617323/
RECORD: Rec_0307241 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Histone H2A-derived peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Cytotoxic
K-562
8.2 μg/mL
IC50
PaperMechanism of anticancer activity of buforin IIb, a histone H2A-derived peptide PMID18617323 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18617323/
RECORD: Rec_0308148 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
S. enteritidis
2 μg/mL
MIC
PMID22306477 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22306477/
RECORD: Rec_0316387 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Histone H2A-derived peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial
SN-12C
11.4 μg/mL
IC50
PaperMechanism of anticancer activity of buforin IIb, a histone H2A-derived peptide PMID18617323 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18617323/
RECORD: Rec_0322935 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Cell-penetrating peptide
Human erythrocytes
200 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/23776609/ PMID23776609 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23776609/
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