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MYP_102099
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Basic Information
Ranatuerin-1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antimicrobial ▸ Antifungal ▸ Fungicidal activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Standard
25 amino acids
C117H204N32O31S3
Standard
Sequence
SMLSVLKNLGKVGLGFVACKINKQC
Physicochemical Analysis
2651.26 Da
9.70
3.44
3.19
0.1375
0.60
0.57
0.18
26.11
116.80
0.0400
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1035.53
-9.48
37.0
38.0
94.0
183.0
1.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0349364 VERIFIED: YES
Provenance & Taxonomy
Aquarana catesbeiana [Animal]
Ranatuerin
8400
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
19-25
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
25.0 μM
MIC
PaperJ.M. Conlon et al. / Biochimica et Biophysica Acta 1696 (2004) 1-14. Antimicrobial peptides from ranid frogs: taxonomic and phylogenetic markers and a potential source of new therapeutic agents Evidence URLhttps://www.uniprot.org/uniprotkb/P82741/entry
RECORD: Rec_0350046 VERIFIED: YES
Provenance & Taxonomy
Lithobates catesbeianus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0373118 VERIFIED: YES
Provenance & Taxonomy
Rana catesbeiana [Animal]
Ranatuerin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans
70 μM
MIC
PMID9784389 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9784389/
RECORD: Rec_0395906 VERIFIED: YES
Provenance & Taxonomy
Lithobates catesbeiana [Animal]
Ranatuerin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
19-25
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus
50 μM
MIC
PMID9784389 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9784389/
RECORD: Rec_0421552 VERIFIED: YES
Provenance & Taxonomy
Rana catesbeiana [Animal]
Ranatuerin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
19-25
Disulfide bridge: C19,C25;
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli
2 μM
MIC
PaperRanatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, green frog Rana clamitan.
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