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MYP_102099
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Basic Information
Ranatuerin-1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antimicrobial ▸ Antifungal ▸ Fungicidal activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Standard
25 amino acids
C117H204N32O31S3
Standard
Sequence
SMLSVLKNLGKVGLGFVACKINKQC
Physicochemical Analysis
2651.26 Da
9.70
3.44
3.19
0.1375
0.60
0.57
0.18
26.11
116.80
0.0400
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1035.53
-9.48
37.0
38.0
94.0
183.0
1.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0097471 VERIFIED: YES
Provenance & Taxonomy
Rana catesbeiana [Animal]
Ranatuerin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
19-25
Disulfide bridge: C19,C25;
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans
70 μM
MIC
PaperRanatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, green frog Rana clamitan.
RECORD: Rec_0113245 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperPatent US 2022/0125873 A1 Evidence URLhttps://patents.google.com/patent/US20220125873A1/en PatentUS 2022/0125873 A1
RECORD: Rec_0120263 VERIFIED: YES
Provenance & Taxonomy
Lithobates catesbeiana [Animal]
Ranatuerin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
19-25
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
PMID9784389 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9784389/
RECORD: Rec_0167686 VERIFIED: NO
Provenance & Taxonomy
Rana catesbeiana [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0211296 VERIFIED: YES
Provenance & Taxonomy
Rana catesbeiana [Animal]
Ranatuerin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
19-25
Disulfide bridge: C19,C25;
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus
50 μM
MIC
PaperRanatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, green frog Rana clamitan.
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