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MYP_102099
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Basic Information
Ranatuerin-1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antimicrobial ▸ Antifungal ▸ Fungicidal activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Standard
25 amino acids
C117H204N32O31S3
Standard
Sequence
SMLSVLKNLGKVGLGFVACKINKQC
Physicochemical Analysis
2651.26 Da
9.70
3.44
3.19
0.1375
0.60
0.57
0.18
26.11
116.80
0.0400
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1035.53
-9.48
37.0
38.0
94.0
183.0
1.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0019095 VERIFIED: YES
Provenance & Taxonomy
Rana catesbeiana [Animal]
Ranatuerin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli
2 μM
MIC
PMID9784389 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9784389/
RECORD: Rec_0048564 VERIFIED: YES
Provenance & Taxonomy
Lithobates catesbeiana [Animal]
Ranatuerin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
19-25
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans
70 μM
MIC
PMID9784389 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9784389/
RECORD: Rec_0049893 VERIFIED: YES
Provenance & Taxonomy
Aquarana catesbeiana [Animal]
Ranatuerin
8400
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
19-25
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
13.0 μM
MIC
PaperJ.M. Conlon et al. / Biochimica et Biophysica Acta 1696 (2004) 1-14. Antimicrobial peptides from ranid frogs: taxonomic and phylogenetic markers and a potential source of new therapeutic agents Evidence URLhttps://www.uniprot.org/uniprotkb/P82741/entry
RECORD: Rec_0051403 VERIFIED: NO
Provenance & Taxonomy
Lithobates catesbeianus [Animal]
Ranatuerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Amphibian defense peptide Antibiotic Antimicrobial Antifungal Fungicide Anti-Candida Hemolytic Non-ribosomal
Qualitative functional evidence
PMID9784389 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9784389/; https://www.uniprot.org/uniprotkb/P82741/entry; https://bblserver.org.in/ampdb/
RECORD: Rec_0065110 VERIFIED: YES
Provenance & Taxonomy
Lithobates catesbeiana [Animal]
Ranatuerin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
19-25
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
human red blood cell
PMID9784389 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9784389/
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