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MYP_102079
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Basic Information
Cholecystokinin-8
Cardiovascular
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Gastrointestinal bioactivity
Hormonal / Endocrine ▸ Hormone peptide
Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Standard
8 amino acids
C49H61N9O14S2
Standard
Sequence
DYMGWMDF
Physicochemical Analysis
1064.19 Da
4.05
-2.24
-2.44
-0.2798
-0.38
0.13
0.28
99.28
0.00
0.3750
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
377.64
-0.21
13.0
14.0
31.0
74.0
4.0
7.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0060892 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Cholecystokinin
10090
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
2:Sulfotyrosine
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Myotropic Receptor modulation
CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion
Experimental: 18 minute; /1080 seconds; Mammalian: 1.1 hour; Yeast: 3 min; E. coli: >10 hour
PaperDegradation of cholecystokinin octapeptide, related fragments and analogs by human and rat plasma in vitro PMID6291099 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/6291099/
RECORD: Rec_0063411 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Cell-Cell Communication Drug Delivery Vehicle Hormones Blood-Brain Barrier
PaperNeuroPedia: neuropeptide database and spectral library PMID21821666 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21821666/
RECORD: Rec_0067535 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Bio-Activity Profile
-
RECORD: Rec_0075317 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Sulphation of Tyrosine residue at position 2
Bio-Activity Profile
Intestinal hormone
HPLC
Human plasma, in vitro; 3000 s
PMID6291099 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/6291099/
RECORD: Rec_0082976 VERIFIED: YES
Provenance & Taxonomy
Notamacropus eugenii [Animal]
Cholecystokinin
9315
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
2:Sulfotyrosine
Bio-Activity Profile
Hormone Endocrine Myotropic Receptor modulation
Experimental: 18 minute; /1080 seconds; Mammalian: 1.1 hour; Yeast: 3 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Cholecystokinin (Notamacropus eugenii): PMID 3375140##6291099 PMID3375140;6291099 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3375140/
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