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MYP_102079
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Basic Information
Cholecystokinin-8
Cardiovascular
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Gastrointestinal bioactivity
Hormonal / Endocrine ▸ Hormone peptide
Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Standard
8 amino acids
C49H61N9O14S2
Standard
Sequence
DYMGWMDF
Physicochemical Analysis
1064.19 Da
4.05
-2.24
-2.44
-0.2798
-0.38
0.13
0.28
99.28
0.00
0.3750
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
377.64
-0.21
13.0
14.0
31.0
74.0
4.0
7.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0042693 VERIFIED: YES
Provenance & Taxonomy
Gallus gallus [Animal]
Gastrin/cholecystokinin
9031
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Tyr2 Sulfotyrosine
Bio-Activity Profile
Hormone Gastrointestinal Neuropeptide
PMID3620999 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3620999/
RECORD: Rec_0049050 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Cholecystokinin
9606
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
2:Sulfotyrosine
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Myotropic Receptor modulation
CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion
Experimental: 18 minute; /1080 seconds; Mammalian: 1.1 hour; Yeast: 3 min; E. coli: >10 hour
PaperDegradation of cholecystokinin octapeptide, related fragments and analogs by human and rat plasma in vitro PMID6291099 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/6291099/
RECORD: Rec_0051309 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
Gastrin/cholecystokinin
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Tyr2 Sulfotyrosine
Bio-Activity Profile
Hormone Gastrointestinal Neuropeptide
PMID2430967 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2430967/
RECORD: Rec_0058061 VERIFIED: YES
Provenance & Taxonomy
Python molurus [Animal]
Gastrin/cholecystokinin
51750
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Tyr2 Sulfotyrosine
Bio-Activity Profile
Hormone Gastrointestinal Neuropeptide
PMID7925386 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7925386/
RECORD: Rec_0059911 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Gastrin/cholecystokinin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Tyr2 Sulfotyrosine
Bio-Activity Profile
Hormone Gastrointestinal Neuropeptide
PMID3620999 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3620999/
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