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MYP_102034
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Basic Information
Alyteserin-1c
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
23 amino acids
C104H176N28O28
Standard
Sequence
GLKEIFKAGLGSLVKGIAAHVAS
Physicochemical Analysis
2266.68 Da
9.70
1.85
1.59
0.0803
0.75
0.48
0.33
-4.61
127.39
0.0435
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
888.02
-7.34
31.0
31.0
78.0
160.0
2.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0115041 VERIFIED: YES
Provenance & Taxonomy
Alytes obstetricans [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
S. suis S10 [
128 μg/mL
MIC
PMID31102497 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31102497/
RECORD: Rec_0115853 VERIFIED: YES
Provenance & Taxonomy
Alytes obstetricans [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
25 μM
MIC
PMID19463738 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19463738/
RECORD: Rec_0116234 VERIFIED: YES
Provenance & Taxonomy
Alytes obstetricans [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Listeria monocytogenes
125 μM
MIC
PMID30764495 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30764495/
RECORD: Rec_0117820 VERIFIED: YES
Provenance & Taxonomy
Alytes obstetricans [Animal]; Bufo obstetricans [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
25 μM
MIC
RECORD: Rec_0130881 VERIFIED: YES
Provenance & Taxonomy
Alytes obstetricans [Animal]
Alyteserin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
250.0 μM
MIC
PaperA.P. Subasinghage et al. / Biochimica et Biophysica Acta 1808 (2011) 1975-1984. Conformational and membrane interaction studies of the antimicrobial peptide alyteserin-1c and its analogue [E4K]alyteserin-1c
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