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MYP_102000
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Basic Information
kT20K mutant
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
29 amino acids
C119H192N36O39S6
Standard
Sequence
GLPVCGETCVGGTCNTPGCKCSWPVCTRN
Physicochemical Analysis
2943.41 Da
7.78
0.70
0.41
0.0242
0.04
0.34
0.10
35.35
43.45
0.0345
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1180.09
-17.51
46.0
46.0
87.0
200.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0129341 VERIFIED: YES
Provenance & Taxonomy
Protein derived [Animal]
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
Alexa-488
Cyclization
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID21873420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21873420/
RECORD: Rec_0142529 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
kT20K
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Alexa Fluor conjugation
Cyclization
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID21873420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21873420/
RECORD: Rec_0148701 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Lysine rsidue labeled with Alexa-488
Cyclization
Bio-Activity Profile
Drug Delivery Vehicle Cell-penetrating peptide
PaperCPPsite: a curated database of cell penetrating peptides PMID22403286 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403286/
RECORD: Rec_0161389 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Hemolytic Antiviral Anti-HIV
Human erythrocytes
25 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/21576247/ PMID21576247 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21576247/
RECORD: Rec_0169762 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]
Cyclotide/kalata
60225
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Fluorophore labeling
Cyclization
5-19, 9-21, 14-26
N-term detail: Lysine rsidue labeled with Alexa-488; backbone cyclization reported in source
Bio-Activity Profile
Cell-penetrating peptide
RAW 264.7; MCF-7
Fluorescence-based uptake assay
PMID21873420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21873420/
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